Common variants at 12ql4 and 12q24 are associated with hippocampal volume
Identifieur interne : 005D83 ( Main/Exploration ); précédent : 005D82; suivant : 005D84Common variants at 12ql4 and 12q24 are associated with hippocampal volume
Auteurs : Joshua C. Bis [États-Unis] ; Charles Decarli [États-Unis] ; Albert Vernon Smith [Islande] ; Fedde Van Der Lijn [Pays-Bas] ; Fabrice Crivello [France] ; Myriam Fornage [États-Unis] ; Stephanie Debette [France, États-Unis] ; Joshua M. Shulman [États-Unis] ; Helena Schmidt [Autriche] ; Velandai Srikanth [Australie] ; Maaike Schuur [Pays-Bas] ; LEI YU [États-Unis] ; Seung-Hoan Choi [États-Unis] ; Sigurdur Sigurdsson [Islande] ; Benjamin F. J. Verhaaren [Pays-Bas] ; Anita L. Destefano [États-Unis] ; Jean-Charles Lambert ; Clifford R. Jr Jack ; Maksim Struchalin [Pays-Bas] ; Jim Stankovich [Australie] ; Carla A. Ibrahim-Verbaas [Pays-Bas] ; Debra Fleischman [États-Unis] ; Alex Zijdenbos ; Tom Den Heijer [Pays-Bas] ; Bernard Mazoyer [France] ; Laura H. Coker ; Christian Enzinger ; Patrick Danoy ; Najaf Amin [Pays-Bas] ; Konstantinos Arfanakis [États-Unis] ; Mark A. Van Buchem ; Renée F. A G. De Bruijn [Pays-Bas] ; Alexa Beiser [États-Unis] ; Carole Dufouil [France] ; JUEBIN HUANG ; Margherita Cavalieri ; Russell Thomson [Australie] ; Wiro J. Niessen [Pays-Bas] ; Lori B. Chibnik [États-Unis] ; Gauti K. Gislason [Islande] ; Albert Hofman [Pays-Bas] ; Aleksandra Pikula [États-Unis] ; Philippe Amouyel ; Kevin B. Freeman ; Thanh G. Phan [Australie] ; Ben A. Oostra [Pays-Bas] ; Jason L. Stein ; Sarah E. Medland ; Alejandro Arias Vasquez ; Derrek P. Hibar ; Margaret J. Wright ; Barbara Franke ; Nicholas G. Martin ; Paul M. Thompson ; Michael A. Nalls ; Andre G. Uitterlinden ; Rhoda Au [États-Unis] ; Alexis Elbaz [France] ; Richard J. Beare [Australie] ; John C. Van Swieten [Pays-Bas]Source :
- Nature genetics [ 1061-4036 ] ; 2012.
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- Pascal (Inist)
English descriptors
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Abstract
Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 x 10-7. In two additional samples (n = 2,318), associations were replicated at 12q14 within MSR83-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10-11) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 x 10-11). Remaining associations included one SNP at 2q24 within DPP4 (rs6741949; P = 2.9 × 10-7) and nine SNPs at 9p33 within ASTN2 (rs7852872; P = 1.0 × 10-7); along with the chromosome 12 associations, these loci were also associated with hippocampal volume (P < 0.05) in a third younger, more heterogeneous sample (n = 7,794). The SNP in ASTN2 also showed suggestive association with decline in cognition in a largely independent sample (n =1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXWB) and neuronal migration (ASTN2), as well as enzymes targeted by new diabetes medications (DPP4), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia.
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Affiliations:
- Australie, Autriche, France, Islande, Pays-Bas, États-Unis
- Aquitaine, Californie, Hollande-Méridionale, Illinois, Massachusetts, Nouvelle-Aquitaine, Texas, Washington (État), Île-de-France
- Bordeaux, Paris, Rotterdam, Seattle
- Université de Washington
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J." last="Verhaaren">Benjamin F. J. Verhaaren</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>15 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name></author><author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1><s2>Hobart, Tasmania</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Hobart, Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name></author><author><name sortKey="Heijer, Tom Den" sort="Heijer, Tom Den" uniqKey="Heijer T" first="Tom Den" last="Heijer">Tom Den Heijer</name><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>15 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name></author><author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name></author><author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A G." last="De Bruijn">Renée F. A G. De Bruijn</name><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>15 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>58 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Juebin Huang" sort="Juebin Huang" uniqKey="Juebin Huang" last="Juebin Huang">JUEBIN HUANG</name></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name></author><author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1><s2>Hobart, Tasmania</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Hobart, Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1><s2>Kopavogur</s2><s3>ISL</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Icelandic Heart Association</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>15 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name></author><author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name></author><author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>45 aut.</sZ><sZ>59 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name></author><author><name sortKey="Arias Vasquez, Alejandro" sort="Arias Vasquez, Alejandro" uniqKey="Arias Vasquez A" first="Alejandro" last="Arias Vasquez">Alejandro Arias Vasquez</name></author><author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>58 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>45 aut.</sZ><sZ>59 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Swieten, John C Van" sort="Swieten, John C Van" uniqKey="Swieten J" first="John C. Van" last="Swieten">John C. Van Swieten</name><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0224070</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0224070 INIST</idno><idno type="RBID">Pascal:12-0224070</idno><idno type="wicri:Area/PascalFrancis/Corpus">001369</idno><idno type="wicri:Area/PascalFrancis/Curation">004B45</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001265</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001265</idno><idno type="wicri:doubleKey">1061-4036:2012:Bis J:common:variants:at</idno><idno type="wicri:Area/Main/Merge">006100</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427729</idno><idno type="RBID">PMC:3427729</idno><idno type="wicri:Area/Pmc/Corpus">002E13</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E13</idno><idno type="wicri:Area/Pmc/Curation">002C63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C63</idno><idno type="wicri:Area/Pmc/Checkpoint">002011</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002011</idno><idno type="wicri:Area/Ncbi/Merge">000D78</idno><idno type="wicri:Area/Ncbi/Curation">000D78</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D78</idno><idno type="wicri:doubleKey">1061-4036:2012:Bis J:common:variants:at</idno><idno type="wicri:Area/Main/Merge">005688</idno><idno type="wicri:Area/Main/Curation">005D83</idno><idno type="wicri:Area/Main/Exploration">005D83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Common variants at 12ql4 and 12q24 are associated with hippocampal volume</title><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of California, Davis</s1><s2>Sacramento, California</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Center of Neuroscience, University of California, Davis</s1><s2>Sacramento, California</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1><s2>Kopavogur</s2><s3>ISL</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Icelandic Heart Association</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Faculty of Medicine, University of Iceland</s1><s2>Reykjavik</s2><s3>ISL</s3><sZ>3 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Der Lijn, Fedde Van" sort="Der Lijn, Fedde Van" uniqKey="Der Lijn F" first="Fedde Van" last="Der Lijn">Fedde Van Der Lijn</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Human Genetics Center, School of Public Health, The University of Texas Health Sciences Center at Houston</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>58 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Institute of Molecular Biology and Biochemistry, Medical University Graz</s1><s2>Graz</s2><s3>AUT</s3><sZ>9 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>45 aut.</sZ><sZ>59 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1><s2>Hobart, Tasmania</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Hobart, Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lei Yu" sort="Lei Yu" uniqKey="Lei Yu" last="Lei Yu">LEI YU</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1><s2>Kopavogur</s2><s3>ISL</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Icelandic Heart Association</wicri:noRegion></affiliation></author><author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>15 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name></author><author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1><s2>Hobart, Tasmania</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Hobart, Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name></author><author><name sortKey="Heijer, Tom Den" sort="Heijer, Tom Den" uniqKey="Heijer T" first="Tom Den" last="Heijer">Tom Den Heijer</name><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>15 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name></author><author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name></author><author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>22 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A G." last="De Bruijn">Renée F. A G. De Bruijn</name><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>15 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>58 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Juebin Huang" sort="Juebin Huang" uniqKey="Juebin Huang" last="Juebin Huang">JUEBIN HUANG</name></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name></author><author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1><s2>Hobart, Tasmania</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Hobart, Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1><s2>Kopavogur</s2><s3>ISL</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Icelandic Heart Association</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>15 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name></author><author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name></author><author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>45 aut.</sZ><sZ>59 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ><sZ>29 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name></author><author><name sortKey="Arias Vasquez, Alejandro" sort="Arias Vasquez, Alejandro" uniqKey="Arias Vasquez A" first="Alejandro" last="Arias Vasquez">Alejandro Arias Vasquez</name></author><author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>16 aut.</sZ><sZ>33 aut.</sZ><sZ>42 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>34 aut.</sZ><sZ>58 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>45 aut.</sZ><sZ>59 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Melbourne, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Swieten, John C Van" sort="Swieten, John C Van" uniqKey="Swieten J" first="John C. Van" last="Swieten">John C. Van Swieten</name><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>11 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>32 aut.</sZ><sZ>60 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Variant</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Variant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 x 10<sup>-7</sup>. In two additional samples (n = 2,318), associations were replicated at 12q14 within MSR83-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10<sup>-11</sup>) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 x 10<sup>-11</sup>). Remaining associations included one SNP at 2q24 within DPP4 (rs6741949; P = 2.9 × 10<sup>-7</sup>) and nine SNPs at 9p33 within ASTN2 (rs7852872; P = 1.0 × 10<sup>-7</sup>); along with the chromosome 12 associations, these loci were also associated with hippocampal volume (P < 0.05) in a third younger, more heterogeneous sample (n = 7,794). The SNP in ASTN2 also showed suggestive association with decline in cognition in a largely independent sample (n =1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXWB) and neuronal migration (ASTN2), as well as enzymes targeted by new diabetes medications (DPP4), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>France</li><li>Islande</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Californie</li><li>Hollande-Méridionale</li><li>Illinois</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Texas</li><li>Washington (État)</li><li>Île-de-France</li></region><settlement><li>Bordeaux</li><li>Paris</li><li>Rotterdam</li><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Arias Vasquez, Alejandro" sort="Arias Vasquez, Alejandro" uniqKey="Arias Vasquez A" first="Alejandro" last="Arias Vasquez">Alejandro Arias Vasquez</name><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name><name sortKey="Juebin Huang" sort="Juebin Huang" uniqKey="Juebin Huang" last="Juebin Huang">JUEBIN HUANG</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name></noCountry><country name="États-Unis"><region name="Washington (État)"><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name></region><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><name sortKey="Lei Yu" sort="Lei Yu" uniqKey="Lei Yu" last="Lei Yu">LEI YU</name><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name></country><country name="Islande"><noRegion><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name></noRegion><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Der Lijn, Fedde Van" sort="Der Lijn, Fedde Van" uniqKey="Der Lijn F" first="Fedde Van" last="Der Lijn">Fedde Van Der Lijn</name></region><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A G." last="De Bruijn">Renée F. A G. De Bruijn</name><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A G." last="De Bruijn">Renée F. A G. De Bruijn</name><name sortKey="Der Lijn, Fedde Van" sort="Der Lijn, Fedde Van" uniqKey="Der Lijn F" first="Fedde Van" last="Der Lijn">Fedde Van Der Lijn</name><name sortKey="Heijer, Tom Den" sort="Heijer, Tom Den" uniqKey="Heijer T" first="Tom Den" last="Heijer">Tom Den Heijer</name><name sortKey="Heijer, Tom Den" sort="Heijer, Tom Den" uniqKey="Heijer T" first="Tom Den" last="Heijer">Tom Den Heijer</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><name sortKey="Swieten, John C Van" sort="Swieten, John C Van" uniqKey="Swieten J" first="John C. Van" last="Swieten">John C. Van Swieten</name><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name></region><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name></country><country name="Autriche"><noRegion><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name></noRegion><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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